Evaluation of synergistic therapeutic effect of shark cartilage extract with artemisinin and glucantime on visceral leishmaniasis in BALB/c mice

Authors

  • Abdolhossein Dalimi Department of Parasitology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  • Fatemeh Ghafarifar Department of Parasitology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  • Soheila Molaie Department of Parasitology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran|Deputy of Research, Ardabil University of Medical Sciences, Ardabil, Iran
  • Zoheir Hassan Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  • Zohreh Sharifi Department of Virology, Iranian Blood Transfusion, Tehran, Iran
Abstract:

Objective(s): Because leishmaniasis is related to the impaired functioning of T-cells, the use of an immunomodulator can increase the efficacy of antileishmanial therapy in visceral leishmaniasis. In this study, we used shark cartilage extract with artemisinin and glucantime against visceral leishmaniasis in BALB/c mice, and evaluated the synergistic therapeutic effect. Materials and Methods: The culturing method and quantitative real-time PCR by using the kDNA gene was used to detect parasite loads in the spleen and liver. INF-γ and IL-4 cytokine levels and survival rates were assayed.Results: The drug therapy with target drugs reduced parasite burden in the spleen and liver significantly. Although parasite burden was lower in the artemisinin treated group than in the glucantime treated group (P

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Journal title

volume 22  issue 2

pages  146- 153

publication date 2019-02-01

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